What are phthalates
Phthalates are diesters of phthalic acids, a family of man-made industrial chemicals extensively used since the early 20th century as softeners of plastics, solvents in perfumes, and additives to hairsprays and lubricants and as insect repellents 1. Phthalates are a class of manufactured chemicals commonly used to increase the flexibility of plastics in a wide array of consumer products. Phthalates that are high-molecular weight, butylbenzyl phthalate (BBzP), di-2-ethylhexyl phthalate (DEHP) and mixtures of di-n-octyl phthalates (DnOP), are most well-known for their use as plasticizers in polyvinyl chloride (PVC) materials such as food packaging, flooring, and medical devices 2. More than 470 million pounds of phthalates are produced or imported in the United States each year 3. By far the most common use of phthalates is in the production of polyvinyl chloride (PVC) products 4. Polyvinyl chloride (PVC) is the second most commonly used plastic in the world, and is present in pipes and tubing, construction materials, packaging, electrical wiring, and thousands of consumer goods 5. Di-2-ethylhexyl phthalate (DEHP) is used primarily as a plasticizer for polyvinyl chloride (PVC) and can therefore be found in a variety of products such as floor and wall coverings, vinyl gloves, toys, child care articles, food packaging materials, and medical devices 6. After absorption, the parent diester phthalates are rapidly hydrolyzed to the corresponding monoesters, some of which are then further metabolized, with the metabolites excreted in urine and feces. In humans, phthalates are eliminated mostly within hours, with excretion complete by a day or two; half-lives in the body are in hours 7. For phthalates with short alkyl chains, monoesters represent the major human metabolite, but in the case of phthalates with long alkyl chains, including DEHP, diisononyl phthalate (DINP) and diisodecyl phthalate (DIDP), the monoesters are further metabolized via ω- and ω-1-oxidation of the aliphatic side chain 8.
Table 1. Phthalate parent compounds and their metabolites
Phthalate name | Abbreviation | Urinary metabolite | Abbreviation |
---|---|---|---|
Dimethyl phthalate | DMP | Mono-n-methyl phthalate | MnMP |
Diethyl phthalate | DEP | Mono-ethyl phthalate | MEP |
Di-isobutyl phthalate | DiBP | Mono-isobutyl phthalate | MiBP |
Di-n-butyl phthalate | DnBP | Mono-n-butyl phthalate | MnBP |
Di-n-octyl phthalate | DnOP | Mono-(3-carboxypropyl) phthalate | MCPP |
Di-isononyl phthalate | DiNP | Mono-carboxyoctyl phthalate | MCOP |
Di-isodecyl phthalate | DiDP | Mono-carboxynonyl phthalate | MCNP |
Benzylbutyl phthalate | BzBP | Mono-benzyl phthalate | MBzP |
Di-2-ethylhexyl phthalate | DEHP | Mono-2-ethylhexyl phthalate | MEHP |
Mono-(2-ethyl-5-hydroxyhexyl) phthalate | MEHHP | ||
Mono-(2-ethyl-5-oxohexyl) phthalate | MEOHP | ||
Mono-(2-ethyl-5-carboxypentyl) phthalate | MECPP |
Phthalates are or have been used in wall coverings, tablecloths, floor tiles, furniture upholstery, carpet backings, shower curtains, garden hoses, rainwear, pesticides, some toys, shoes, automobile upholstery, food packaging, medical tubing, and blood storage bags 10. Phthalates are not strongly bound in these products and can therefore leach out 11. Some phthalates are also present in cosmetics, nail polish, hair products, skin care products, and some medications 12. In recent years, di-nonyl phthalate (DiNP) and di-decyl phthalate (DiDP) have increasingly replaced DEHP in these applications 13. Alternatively, low-molecular weight phthalates, dimethyl phthalate (DMP), diethyl phthalate (DEP) and dibutyl phthalate (DBP), are primarily added to cosmetics and personal care products as solvents, fixatives and adhesives 14. Due to non-covalent bonds between the phthalate chemicals and their parent materials, there can be significant leaching and volatilization leading to environmental contamination and thus ubiquitous exposures in the general population. In fact, a recent report showed that metabolite biomarkers of eight major phthalates have been detected in 89% to 98% of the United States (US) population 13.
Phthalates are used in many consumer products, including:
- Cosmetics and personal care products
- Plastic and vinyl toys
- Shower curtains
- Miniblinds and wallpaper
- Vinyl flooring
- Raincoats
- Food packaging and wraps
- Detergents
- Adhesives
- Plastic pipes
- Medical equipment and devices
- Polyvinyl chloride (PVC) plastics
Phthalates commonly enter(s) the body through:
- Ingestion (swallowing): Eating food or water packaged in plastic, or drinking water contaminated with phthalates; for children, chewing on soft vinyl toys or products made with phthalates
- Inhalation (breathing): Breathing dust in rooms with plastic miniblinds, wallpaper, or flooring that contain phthalates
- Skin contact: Touching or using products made with phthalates
For most phthalates, the major route of exposure is food ingestion 5. However, personal care product use and inhalation are major routes of exposure for certain phthalates 15. Some phthalates have been found at higher levels in fatty foods such as dairy products, fish, seafood, and oils 16. Phthalates in a mother’s body can enter her breast milk. Ingestion of that breast milk and infant formula containing phthalates may also contribute to infant phthalate exposure 17. The phthalates that may be present in dust can be ingested by infants and children through hand-to-mouth activities 18. Finally, infants and small children can be exposed to phthalates by sucking on toys and objects made with phthalate-containing plastics 11.
Other minor routes of phthalate exposure include inhalation, drinking contaminated water, and absorption through the skin 19. Phthalates can be released in small amounts to the air people breathe inside homes or schools from the many consumer products that contain them 20. People living near phthalate-producing factories or hazardous waste sites may be exposed to phthalates released into the air or ground water where they live 16. Individuals may be exposed to phthalates during the use of many personal care products containing phthalates, such as hair products, cosmetics, and lotions 21. Phthalates in these products may be absorbed through contact with the skin or may be inhaled if some of the product is present in the air. In addition, certain medical devices, such as intravenous tubing or flexible bags containing blood, medications, or nutritional products, contain phthalates. These can be a source of phthalate exposure to children and women of child-bearing age when the tubing or bags are used to administer medications, nutritional products, or blood to the individual. This can be a very significant route of exposure, especially for premature infants in intensive care units 22.
Phthalate exposures, assessed from urinary concentrations of phthalate metabolites (i.e., breakdown products), appear to be higher for children compared with adolescents and adults. Studies of phthalate metabolites in children’s urine are limited, but the few that have been published have found children’s urinary phthalate metabolite levels to be higher than levels in adults and to decrease with age (i.e., younger children had more phthalate metabolites in their urine than older children did) 23. The exception is monoethyl phthalate (MEP), a metabolite of diethyl phthalate, which has been found to be present in higher levels in adult urine compared with children’s urine 23. Levels of monoethyl phthalate (MEP) are most likely associated with use of consumer products that contain diethyl phthalate, such as detergents, soaps, cosmetics, shampoos, and perfumes 23.
Phthalates health effects
Some phthalates are suspected endocrine disruptors 24. Endocrine disruptors act by interfering with the biosynthesis, secretion, action, or metabolism of naturally occurring hormones 24. Given the importance of hormones in human physiology, there is concern in the scientific community over the potential for endocrine disruptors to adversely affect children’s health, particularly in reproduction, development, and behavior. Male laboratory animals exposed to high doses of some phthalates have been known to display elements of “phthalate syndrome,” which includes infertility, decreased sperm count, cryptorchidism (undescended testes), hypospadias (malformation of the penis in which the urethra does not open at the tip of the organ), and other reproductive tract malformations 5. A number of animal studies have reported associations between exposure to certain phthalates and changes in male hormone production, altered sexual differentiation, and changes to reproductive organs, including hypospadias 25. These findings in animal studies, although typically occurring at exposure levels much higher than what the general population may be exposed to, suggest a potential concern for health effects in children as well. The National Research Council has concluded that prenatal exposure to certain phthalates produces reproductive tract abnormalities in male rats, and also concluded that the same effects could plausibly occur in humans 5.
There are only a limited number of human studies looking at the relationship between phthalate exposure and hormonal and reproductive health changes. In one study, prenatal exposure to some phthalates (DEP, diisobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP) and DEHP) at typical U.S. population levels was associated with changes in physical measures of the distance between the anus and the genitals (anogenital distance) in male infants, a marker of androgenization 26. A shorter anogenital distance has been associated with decreased fertility in animal experiments 27 and a recent human study reported that a shorter anogenital distance in men was associated with decreased semen quality and low sperm count 28. Another study reported an association between increased concentrations of phthalate metabolites in breast milk and altered reproductive hormone levels in newborn boys. The same study did not find an association between breast milk phthalate metabolite concentrations and cryptorchidism 29.
Exposure to some phthalates has been associated with neurodevelopmental problems in children in some studies. Two studies of a group of New York City children ages 4 to 9 years reported associations between prenatal exposure to certain phthalates and behavioral deficits, including effects on attention, conduct, and social behaviors 30. Studies conducted in South Korea of children ages 8 to 11 years reported that children with higher levels of certain phthalate metabolites in their urine were more inattentive and hyperactive, displayed more symptoms of attention-deficit/hyperactivity disorder (ADHD), and had lower IQ compared with those who had lower levels 31. The exposure levels in these studies are comparable to typical exposures in the U.S. population.
A handful of studies have reported associations between prenatal exposure to some phthalates and preterm birth, shorter gestational length, and low birth weight 32; however, one study reported phthalate exposure to be associated with longer gestational length and increased risk of delivery by Cesarean section 33.
In adult populations, various epidemiological studies support an association between phthalate exposure and markers of testicular function in men, particularly decreased semen quality 34. There is also evidence linking endometriosis in women with high phthalate metabolite levels 35. Increases in waist circumference and body mass index (BMI) have been linked to DEHP, BzBP, DBP and DEP exposure in men and DEP exposure in adolescent and adult females 36. One of the replacements for the DEHP, DiNP, has recently been designated as a carcinogen in the State of California 37.
Finally, some researchers have hypothesized that phthalate exposure in homes may contribute to asthma and allergies in children. Two research groups have conducted studies, primarily in Europe, and reported associations between surrogates for potential phthalate exposure in the home and risk of asthma and allergies in children 38. Examples of the exposure indicators and outcomes considered in these studies include an association between some phthalates in surface dust and increased risk of runny nose, eczema, and asthma 39 and increased risk of bronchial obstruction associated with the presence of PVC in the home 40.
In 2006, the National Toxicology Program (NTP) concluded that there is “concern” for effects on reproductive tract development in male infants less than one year old exposed to DEHP. In addition, the National Toxicology Program also concluded that there is “some concern” (the midpoint on a five-level scale ranging from “negligible” to “serious” concern) for effects on reproductive tract development in male children older than one year old exposed to DEHP, and also that there is “some concern” for effects of prenatal DEHP exposure on reproductive tract development in males 41. Concern was greater for males exposed to high levels of DEHP in the womb or early in life. These conclusions were based primarily on findings from animal studies, as human data are limited and were determined to be insufficient for evaluating the reproductive effects of DEHP 42. Some studies have also reported associations of DEHP exposure with increased risk of asthma and bronchial obstruction, increased risk of ADHD symptoms, and altered pregnancy durations 39. Human health studies have reported associations between exposures to DBP and altered reproductive hormone levels in newborn boys, and shifts in thyroid hormone levels in pregnant women 43. Signs of feminization in young boys (as measured by reduced anogenital distance), altered hormone levels in newborn boys, and increased risk of rhinitis and eczema are health effects that have been associated with BBzP exposure in some studies 39. The exposure levels in these studies are comparable to typical exposures in the U.S. population. It is important to note that while the following indicators present data on individual phthalate metabolites, evidence suggests that exposures to multiple phthalates may contribute to common adverse outcomes. The National Research Council has concluded that multiple phthalates may act cumulatively to adversely impact male reproductive development 5.
Phthalates in food
Given the increasing scientific evidence base linking phthalate exposure with harmful health outcomes, it is important to understand major sources of exposure. A recent and well-designed study by Koch et al. 44 that monitored urinary phthalate excretion in individuals fasting for 48 hours, found that diet was the most significant pathway for exposures to DEHP, DiNP and DiDP while DMP, DEP, DiBP, DnBP and BBzP were primarily linked to non-food exposures. According to a review by Cao 45, phthalates can migrate into food from plasticized PVC materials such as tubing typically used in the milking process, lid gaskets, food-packaging films, gloves used in the preparation of foods, and conveyor belts. These compounds are also found in printing inks and adhesives on food wrappers as well as coatings on cookware that have been contaminated by packaging 46. Foods high in fat are contaminated by higher weight phthalates that are more lipophilic such as DEHP 45. In the United States, phthalates have been approved by the Food and Drug Administration (FDA) as plasticizers in food packaging materials and food contact substances used during processing and storage while the European Commission and Chinese authorities have limited phthalates in food contact materials made of plastic since 2008–2009 47. Thus, there can be substantial variability in phthalate concentrations within food groups based on the region of food production, processing practices, presence and type of packaging and lipid content 48. With an ever increasing global market, phthalate contamination is a food safety issue that crosses international borders. Dietary phthalate exposure assessment has become a topic of great interest given the significance of the dietary pathway and health impacts associated with the specific phthalate species found in food.
The review of the literature revealed that poultry, some dairy products (cream) and fats are routinely contaminated with high concentrations of DEHP than other foods 9. Milk, yogurt, eggs, fruits, vegetables, pasta, noodles, rice, beverages and water were found to contain low concentrations of phthalates as a whole 9.
Foods with High DEHP Concentrations (>300 μg/kg)
- Poultry
- Cream
- Cooking Oils/Fats
Foods with Low DEHP Concentrations (<50 μg/kg)
- Yogurt, Eggs
- Pasta, Rice, Noodles
- Fruits/vegetables
- Beverages
Given the chemistry of high molecular weight phthalates like DEHP, higher concentrations in lipid rich foods were expected. There was significant variability in concentration observed between dairy products based on typical fat content. Among the dairy products tested, cream and cheese were more heavily contaminated across studies in comparison to yogurt 9. Poultry consistently had higher phthalate content than other meats, however it is unclear what factors impacted these results since details as to the fat content of products was not always reported. Noteworthy, phthalates in non-fatty foods including bread and cereal products were observed in variable concentrations. This is of importance since two recent studies conducted in Belgium 49 and Germany 50 reported bread as a significant source of DEHP and highest contributor to total exposures in the general adolescent and adult population at 31.4% and 14.06%, respectively. Sources of contamination may be present in the processing of grains, though this is unclear. As a whole, food monitoring data also suggests that the consumption of fruit and vegetables is associated with limited phthalate exposures. However, processed fruit and vegetable products found in jars appear to contribute to greater exposures given the high concentrations reported.
Figure 1. Phthalates exposures through diet per capita
[Source 51]As expected, the epidemiology literature reported that dairy products, meats and discretionary fat intake, in fact, were associated with increases in DEHP urinary metabolite levels in adolescent and adult populations. Furthermore, consumption of these products were found to be associated with MnBP levels in one epidemiology study and elimination of some of these products from the diet (dairy and meat) led to a decrease in MnBP and DEHP metabolites in the Temple Stay intervention 52. It is important to note that although results from Ji and others suggest that discontinuing meat and dairy from the diet may be largely responsible for decreases in metabolite levels, there may have been other factors in the environment that impacted results since details of the diet as well as daily practices in the Temple Stay program were not available 53. It is possible that decreases in low molecular weight phthalates, given their primary source, could be attributed to reduced use of personal care products rather than changes in the diet 53.
Results between food monitoring and epidemiological data were not completely consistent. Two epidemiology studies reported an association between fish consumption and MiBP; however the food monitoring data did not support this result as all DiBP levels in seafood were found to be low across studies. Additionally, increased levels of MMP (a metabolite of DMP) were associated with consumption of fruit while the food monitoring data did not show DMP at significant levels for this food group 54. Finally, Colacino et al. 55 as well as Trasande et al. 56 reported positive associations between vegetables and MEP. However, the food monitoring data does not support this finding and two other epidemiology studies 57, 58 suggest that diets with high consumption of fruits and vegetables may be associated with decreases in DEP exposure.
Phthalates in cosmetics
Historically, the primary phthalates used in cosmetic products have been dibutylphthalate (DBP), used as a plasticizer in products such as nail polishes (to reduce cracking by making them less brittle); dimethylphthalate (DMP), used in hair sprays (to help avoid stiffness by allowing them to form a flexible film on the hair); and diethylphthalate (DEP), used as a solvent and fixative in fragrances. According to FDA’s latest survey of cosmetics, conducted in 2010, DBP and DMP are now used rarely. DEP is the only phthalate still commonly used in cosmetics 59.
In 2002, the Cosmetic Ingredient Review Expert Panel 60 reaffirmed its original conclusion (reached in 1985), finding that DBP, DMP, and DEP were safe as used in cosmetic products. Looking at maximum known concentrations of these ingredients in cosmetics, the Cosmetic Ingredient Review Expert Panel 60 evaluated phthalate exposure and toxicity data, and conducted a safety assessment for dibutylphthalate in cosmetic products. The Cosmetic Ingredient Review Expert Panel 60 found that exposures to phthalates from cosmetics were low compared to levels that would cause adverse effects in animals. The Cosmetic Ingredient Review Expert Panel is an industry-sponsored organization that reviews cosmetic ingredient safety and publishes its results in open, peer-reviewed literature. The FDA participates in Cosmetic Ingredient Review on a non-voting basis and may or may not accept Cosmetic Ingredient Review Expert Panel findings 59.
The FDA reviewed the safety and toxicity data for phthalates, including the Centers for Disease Control and Prevention (CDC) data from 2001 61, as well as the Cosmetic Ingredient Review Expert Panel 60 conclusions based on reviews in 1985 and 2002. While the Centers for Disease Control and Prevention (CDC) report noted elevated levels of phthalates excreted by women of child-bearing age, neither this report nor the other data reviewed by FDA established an association between the use of phthalates in cosmetic products and a health risk. Based on this information, FDA determined that there wasn’t a sound, scientific basis to support taking regulatory action against cosmetics containing phthalates 59.
The FDA continues to monitor levels of phthalates in cosmetic products. The FDA have developed an analytical method for determining the levels of phthalates in cosmetic products and conducted surveys of products to determine these levels in cosmetics on the market.
What we know about infant exposure to phthalates
Infants, like all consumers, are exposed daily to phthalates from a number of sources, including air, drugs, food, plastics, water, and cosmetics.
The American Academy of Pediatrics has published an article stating that infants exposed to infant care products, specifically baby shampoos, baby lotions, and baby powder, showed increased levels of phthalate metabolites in their urine 62.
Like the CDC report, this study did not establish an association between these findings and any health effects. In addition, levels of phthalates, if any, in the infant care products were not determined.
The FDA included 24 children’s products intended for infants and children in the survey we completed in 2006, and nearly 50 products for infants and children in the survey we completed in 2010. What the FDA have learned was that the use of phthalates in cosmetics intended for people of all ages, including infants and children, has decreased considerably since the surveys began in 2004.
How to know if there are phthalates in the cosmetics you use
Under the authority of the Fair Packaging and Labeling Act, the FDA requires an ingredient declaration on cosmetic products sold at the retail level to consumers. Consumers can tell whether some products contain phthalates by reading the ingredient declaration on the labels of such products.
However, the regulations do not require the listing of the individual fragrance ingredients; therefore, the consumer will not be able to determine from the ingredient declaration if phthalates are present in a fragrance. Also, because the Fair Packaging and Labeling Act does not apply to products used exclusively by professionals–for example, in salons–the requirement for an ingredient declaration does not apply to these products. Based on available safety information, DEP does not pose known risks for human health as it is currently used in cosmetics and fragrances. Consumers who nevertheless do not want to purchase cosmetics containing DEP may wish to choose products that do not include “Fragrance” in the ingredient listing.
Results of FDA’s 2010 Survey of Cosmetics for Phthalate Content
The products listed below represent a sample of cosmetics on the market at the time the survey was conducted, and products may have been reformulated since then. This survey was intended to monitor trends in the use of phthalates in cosmetics, not as a comprehensive analysis of all cosmetics on the market. The law does not require cosmetic firms to file their formulations with FDA. Also, note that some so-called “personal care products,” such as diaper creams and nipple creams, are regulated as drugs, or in some cases both cosmetics and drugs.
Table 2. 2010 Survey of Cosmetics for Phthalate Content
Product Type | Brand | Lot # | Phthalates (ppm) | ||
---|---|---|---|---|---|
DMP | DEP | DBP | |||
Nail Polish | Pure Ice – Spit Fire | 991CP | |||
Dora the Explorer Mega Nail Polish Kit – Townley | WO90817 | ||||
Scherer Nail Polish CQ #143 Cabernet | Not visible | ||||
Rimmel Lycra Wear 10 Days Nail Polish #303 Vintage | 732318 | ||||
In a New York Color Minute 224B | 8MBCK | ||||
Sally Hansen Diamond Strength #45 Fuchsia | 8MSHK | ||||
Hard Candy Just Nails (Glitter) | 9226 | ||||
Petites Pink Crush 270 – CQ | Not visible | ||||
Revlon Nail Enamel Red Hot Tamale 908 | Not visible | ||||
Maybelline Express Finish Grape Times 608 | WF224 | ||||
Nicole by OPI Razzle Dazzler | 09295AAG | ||||
Scherer Nail Polish CQ #107 Crystal Clear | Not visible | ||||
LA Colors Nail Lacquer Red Stilettos CBLQ 389 | Not visible | ||||
LA Colors Art Deco Polish Silver Glitter CBNA 502 | Not visible | ||||
LA Colors Nail Hardener-Strengthener | 9796 | ||||
Hot Topic Nail Polish Black | Not visible | ||||
Hot Topic Nail Polish Green | Not visible | ||||
Hot Topic Nail Polish Purple | Not visible | ||||
Hot Topic Nail Polish (Skull) Green | Not visible | 4,800 | |||
Hot Topic Nail Polish (Skull) Black | Not visible | 4.4 | |||
Hot Topic Nail Polish (Skull) Yellow | Not visible | 4 | |||
Simple Pleasures Nail Polish “Peace” (Glitter) | Not visible | ||||
Simple Pleasures Nail Polish “Love” (Pink) | Not visible | ||||
WetnWild Wild Shine 410A | 918201 | ||||
Sinful Colors Professional Nail Polish Enamel Pinky Glitter 830 | Not visible | ||||
Sinful Colors Under 18 | Not visible | ||||
Borghese Nail Lacquer Vernis Botticelli Nude | 6KXJKC | 3.4 | |||
Sally Hansen High Definition 04 (Green) | 9MHYK | ||||
Cover Girl Boundless Base Coat Nail Color Red Revolution 553 | 7239HV | ||||
Cover Girl Boundless Base Coat Nail Color Gold Rush 415 | 9139HV | ||||
Sally Hansen Hard As Nails Xtreme Wear Hot Magenta 03 | 6MTXK | ||||
Sally Hansen Salon Lacquer Nail Polish Orange You Cute? 450 | 8JFDK | 6.6 | |||
Sally Hansen Insta-Dri Rose-a-go-go 06 | AKVDKN | ||||
Sally Hansen Diamond Strength 33 Champagne Toast | 8M8OK | ||||
Avon Nailwear Pro Nail Enamel Polish Midnight Plum | VEK19 | ||||
Skin Cream and Lotion | Red Velvet Body Lotion – Gift Pack | H8920109 | |||
Dove Deep Moisture Nourishing Body Wash with NutrimMoisture | 10079PP23S | ||||
Eucerin Plus Intensive Repair Hand Crème with Dry Skin Therapy | 90125515 | ||||
Aveeno Active Naturals Daily Moisturizing Lotion | 1129LK | ||||
Vaseline Sheer Infusion Vitamin Burst Body Lotion | 08149UM42 | ||||
Palmer’s Cocoa Butter Formula Concentrated Cream | N9215A | ||||
Jergens Ultra Healing Extra Dry Skin Moisturizer | Y225106ZZA | ||||
Ponds Dry Skin Cream | 08289HU87 | ||||
Dollar General Guarantee Skin Rescue Moisture Lock Lotion | C9A129 | ||||
Noxzema The Original Deep Cleansing Cream with Eucalyptus Oil | Rubbed out | ||||
Suave Powder Fresh Body Lotion | 10289JU41 | ||||
Celine Dion Sensational Shimmering Body Lotion | 92251 | ||||
Scentsations by Body Source Cherry Blossom Body Lotion | M9290AL18 | ||||
Walgreens Advanced Care (Fragrance Free) | 0401609 | ||||
Curel Continuous Comfort Original Formula Moisturizer | X140106ZZA | ||||
Lubriderm Daily Moisture Lotion, Normal to Dry Skin, Fragrance Free | 0118C | ||||
Nivea Soft Refreshingly Soft Moisturizing Crème | 73729160 | 100 | |||
Bath, Body, etc… Organic Soothing Aloe Vera Body Lotion | 29473 | 260 | |||
J.R. Watkins Natural Apothecary Hand & Body Lotion | 0374579 | ||||
Jergens Original Scent Cherry-Almond Moisturizer | W106125ZZ | 110 | |||
Palmer’s Cocoa Butter Formula with Vitamin E Skin Therapy Oil | Rubbed out | ||||
St. Ives Hydrating Vitamin E Advanced Body Moisturizer | 09327021103 | ||||
Vaseline for Men Hand Lotion | 05279HU09 | ||||
Corn Huskers Heavy Duty Oil-Free Hand Treatment Lotion | 2969G | ||||
Malibu Hemp Moisturizer Body Lotion for Dry Skin | 5434 | ||||
Keri Original Dry Skin Lotion | 23654901 | ||||
Avon Haiku Perfumed Skin Softener | MK091 | ||||
Avon Jet Femme Body Lotion | MLP81 | ||||
Avon Candid Perfumed Skin Softener | MAN91 | ||||
Avon Moisture Therapy Intensive Extra Strength Cream | MIV91 | ||||
Fragrance | Dove Go Fresh Body Mist | 090495U49 | |||
Jovan Island Gardenia Cologne Spray | 9218 | 14,000 | |||
Love’s Baby Soft Cologne Spray | 0906D48 | ||||
A Little Sexy Body Spray by Parfums de Coeur | 09324 | ||||
Axe Instinct Body Spray | 03119KK09 | ||||
Curve Crush Body Mist | 9JA02 | ||||
Bodycology Sweet Petals Body Mist | S9J27AK | ||||
Cotton Candy Body Spray Prince Matchabelli | 09267 | ||||
Degree Classic Romance Body Mist | 4068 | ||||
Hannah Montana Cologne Spray | 3169Y | ||||
Wanna Play Body Spray Parfums de Coeur | 09294 | 3,800 | |||
Chantilly – Walmart Gift Pack | 090723A | 7,300 | |||
Tabu – Walmart Gift Pack | 090721A | 6,200 | |||
Heaven Sent – Walmart Gift Pack | 090622B | 1,300 | |||
Navy – Walmart Gift Pack | 090722C | 40,000 | |||
English Leather – Walmart Gift Pack | 090721A | 3,900 | |||
British Sterling – Walmart Gift Pack | 090526A | 480 | |||
Canoe – Walmart Gift Pack | 0907248 | 2,000 | |||
English Leather Black – Walmart Gift Pack | 0907916 | ||||
Johnson’s Baby Cologne | 1919COB128135 | ||||
Barbasol After Shave Pacific Rush | 60161 | ||||
Aqua Velva Classic Ice Blue | R09K174 | 760 | |||
Tattooed by Inky | Not visible | ||||
BOD Really Ripped Abs | 8TZ60 | 6,200 | |||
i Carly | 168961B | ||||
Baby Cream and Lotion | Johnson’s Baby Lotion | 2519T | |||
Dollar General Sleepy Time Baby Lotion | 8KF1025 | ||||
Baby Avalon Organics Protective A,D & E Ointment | 6H01 | ||||
Huggies Naturally Refreshing (Green Tea & Cucumber) Lotion | CU6287282 | ||||
Baby Magic Gentle Baby Lotion | 9237 | ||||
Burt’s Bees Baby Bee Buttermilk Lotion | 0850801 | ||||
Aveeno Baby Soothing Relief Moisture Cream | 0209D | ||||
Parent’s Choice Baby Lotion | 0034311 | ||||
Johnson’s Bedtime Lotion | 1759G | ||||
Johnson’s Head-to-Toe Fragrance Free Baby Lotion | 0049LK | ||||
Johnson’s Shea and Cocoa Butter Baby Cream | 0069VB | ||||
Susan Brown’s Baby Sensitive Baby Lotion-to-powder | 10577A | ||||
California Baby Calming Everyday Lotion | CB9303A2 | ||||
Deodorant | Brut 24-Hour Protection deodorant | 11029TR53 | 22 | ||
Tom’s of Maine Natural Care Lavender Deodorant Stick | LD1370 | ||||
Old Spice High Endurance Deodorant | 9307TN | ||||
Axe Fresh Action Essence Deodorant | 08129UR16 | ||||
Degree Men Deodorant Silver Ion Intense Sport | 11209UR39 | 2.9 | |||
Speed Stick Ocean Surf Deodorant | 9270502 | ||||
Personal Care Clear Stick Deodorant | 08123A | ||||
Kiss My Face Active Enzyme Lavender Deodorant | KO73008B | ||||
Dove Powder Invisible Solid | 09229UR86 | ||||
Secret Powder Fresh | 9068TN | 34 | |||
Hair Products | Biosilk Rock Hard Gelee Firm Hold | C8200 | |||
Garnier Fructis Style Body Boost Volumizing Gel | 48F6030 | ||||
TRESemmé No Frizz Shine Spray | 09308TA20SDSIL2506 | 22 | |||
Suave Professionals Styling Foam Extra Hold | 11129KK61 | 52 | |||
Rave 4X Mega Unscented Hair Spray | 11199HU63 | 16 | |||
White Rain Unscented Extra Hold Hair Spray | 287CP3475403SDSIL15001 | 61 | |||
Short Sexy Hair Quick Change Shaping Balm | 09219 | ||||
American Crew Forming Cream | F952CIOC | 50 | |||
Dep Sport Endurance Styling Gel | R2029932A2 | 6.8 | |||
TRESemme Tres Two Extra Hold Hair Spray | 09313AA1416 | 37 | |||
John Frieda Collection Frizz-Ease Mousse | Y223DK17DDT2Q | ||||
Aussi Catch the Wave Mousse & Conditioner | 92755398F | ||||
Catwalk Extra Strong Mousse | 233748783122142 | 23 | |||
Johnson’s No More Tangles Detangling Spray | 0489VA | ||||
Manic Panic Amplified Semi-Permanent Hair Color Cream | 10922 | ||||
Color Fiend Blood Red Temporary Comb-In Color | RN0709 | ||||
Color Fiend Pink Pop Water Based Semi-Permanent Hair Color | Not visible | ||||
Shampoo | Johnson’s Baby Shampoo | 2118T | |||
Suave Kids 2 in 1 Shampoo Smoothers Cowabunga Coconut | 081491J18 | ||||
Ave Dual 2 in 1 Shampoo + Conditioner | 01139TJ27 | 17 | |||
Pantene Pro-v Moisture Renewal Hydration Quotidienne Shampoo | 93005401E1 | ||||
Aveeno Baby Essential Moisture Shampoo | 0099VA | ||||
Big Sexy Hair Big Volume Shampoo | 09205150 | 210 | |||
Garnier Fructis Fortifying Shampoo Color Shield | EF036 | ||||
Dove Intense Damage Therapy Shampoo | 08299JU39 | ||||
VO5 Normal Balancing Shampoo | 09316020758 | 440 | |||
Suave Professionals Sleek Shampoo | 07109JU41 | ||||
Finesse Self Adjusting Moisturizing Shampoo | 9234M | ||||
Herbal Essences Hello Hydration Moisturizing Shampoo | 93145395LF | ||||
TRESemmé Smooth and Silky Touchable Softness | 09231C1130 | ||||
Advance Techniques Color Reviving Shampoo | MK191 | 82 | |||
Avon High School Musical Raspberry Roarin’ 2-in-1 Shampoo | MKW91 | ||||
Body Wash | Caress Daily Silk Silkening Body Wash | 10159UR022010 | |||
Equate Tropical Fresh Body Wash with Exfoliating Pomegranate Seed | A50298-9328C1 | ||||
Caress Tahitian Renewal Silkening Body Wash | 08069TJ37 | ||||
Olay Body Ultra Moisture with Shea Butter Body Wash | 92595395WA | ||||
Suave Naturals Cucumber Melon Rejuvenating Body Wash | 11109J038 | ||||
Suave Men Body Wash Active Sport | 09169CU05 | 10 | |||
White Rain All Day Moisturizing Body Wash | 093203 | ||||
Dove Sensitive Skin Beauty Body Wash | 03049PP05 | ||||
Natural Concepts Sensitive Skin Body Wash | A48292926583 | 340 | |||
Dial Clean and Soft Moisturizing Body Wash | Q89M0310806091102 | ||||
St. Ives Renewing Collagen Elastin Moisturizing Body Wash | 09345181020141 | ||||
Natural Concepts Natural Blends Body Wash Violet & Pea | A40128-8353C1 | ||||
Avon Naturals Strawberry & Guava Shower Gel | Rubbed out | ||||
Avon Bubble Bath Bain-mousse Vanilla Cream for Dry Skin | MLK91 | ||||
High School Musical Strawberry Sudsin’ Body Wash | MLC91 | ||||
Nipple Cream | Lansinoh HPA Lanolin for Breastfeeding Mothers | 39982 | |||
Gerber Breast Therapy Moisturizing Balm | BK07A02UU | ||||
Children’s Makeup | Kiss Me 2 Gift Pack Blush – Markwins | ||||
Kiss Me 2 Gift Pack Eye Shadow – Markwins | 1090075 | ||||
Hard Candy in the Shadows Eye Shadow Collection | 9260 | ||||
Claire’s Cosmetics Eye Shadow | 11/09 | ||||
Claire’s Cosmetics Eye Glitter | DR911333 | ||||
Diaper Cream | Butt Butter Organics Herbal Diaper Rash Treatment | 31823 | |||
Burts Bees Baby Bee Diaper Ointment | 1070801 | ||||
Baby’s Bliss Diaper Cream | 1386 | 130 | |||
Lavera Baby & Kinder Neutral | 2897 | ||||
Weleda Baby Calendula Baby Cream | 902212 | ||||
Wet Wipes | Pull-ups Flushable Moist Wipes | MK929202A | |||
Equate Flushable Wipes All Purpose | 09295D209651416 | ||||
Pure’n Gentle Fragrance Free Wipes | 09272C230400512 | ||||
Huggies Soft Skin Baby Wipes | MK914804A | ||||
My Fair Baby Baby Wipes | 38091679169 | ||||
Infant Soap, Shampoo, Body Wash | Johnson’s Head to Toe Baby Wash | Rubbed out | |||
Body Sense Baby Wash with Shea & Cocoa butter | OU28781 | ||||
My Fair Baby Baby Wash with Camomile | 608015001/A2 | 60 | |||
Burts Bees Baby Bees Shampoo and Wash | 2280801 | ||||
Avon Bubble Bath Bain-mousse for Kids | MKY91 | ||||
Aubrey Organics – Natural Baby & Kids Bath Soap | 11249 | ||||
Baby Oil | Johnson’s Baby Oil | 2339G | |||
Equate Delicate Baby Oil | 0031646 | ||||
Burt’s Bees Baby Bee Apricot Baby Oil | 0460801 | ||||
Face & Body Paint | Claire’s Cosmetics Body Glitter | 07/09 | |||
Claire’s Cosmetics Vanilla Glitter Body Mist | 0929301 | 390 | |||
Alex Face Paint Studio – Face Paint | 9012LP | ||||
Snazaroo Face Painting Kit | T190803 | ||||
Glitter Gel | Hard Candy Glitteratzi Eye Glitter Gel | 9301 | |||
Claire’s Club Scented Body Glitter | 4926 | 167 | |||
Alex Face Paint Studio – Pink Glitter Gel | 9B2351 | ||||
Baby Powder | Johnson’s Baby Powder | 2528RA | |||
Body Sense Baby Powder | 9DG0797 | ||||
Burt’s Bees Baby Bee Dusting Powder | Not visible |
- Schecter A, Lorber M, Guo Y, et al. Phthalate Concentrations and Dietary Exposure from Food Purchased in New York State. Environmental Health Perspectives. 2013;121(4):473-479. doi:10.1289/ehp.1206367. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620091[↩]
- Phthalates. https://www.epa.gov/sites/production/files/2017-08/documents/phthalates_updates_live_file_508_0.pdf[↩]
- U.S. Environmental Protection Agency. 2012. Phthalates Action Plan. Washington, DC: U.S. EPA. http://www.epa.gov/oppt/existingchemicals/pubs/actionplans/phthalates_actionplan_revised_2012-03-14.pdf[↩]
- Thornton, J. 2000. Pandora’s Poison: Chlorine, Health, and a New Environmental Strategy. Cambridge, Massachusetts: MIT Press.[↩]
- National Research Council. 2008. Phthalates and Cumulative Risk Assessment: The Tasks Ahead. Washington, DC: The National Academies Press. http://www.nap.edu/catalog/12528/phthalates-and-cumulative-risk-assessment-the-tasks-ahead[↩][↩][↩][↩][↩]
- Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants. Green R, Hauser R, Calafat AM, Weuve J, Schettler T, Ringer S, Huttner K, Hu H. Environ Health Perspect. 2005 Sep; 113(9):1222-5.[↩]
- Human body burdens of chemicals used in plastic manufacture. Koch HM, Calafat AM. Philos Trans R Soc Lond B Biol Sci. 2009 Jul 27; 364(1526):2063-78.[↩]
- Agency for Toxic Substances and Disease Registry. Atlanta, GA: Agency for Toxic Substances and Disease Registry; 2002. Toxicological Profile for Di-(2-ethylhexyl) Phthalate [DEHP][↩]
- Serrano SE, Braun J, Trasande L, Dills R, Sathyanarayana S. Phthalates and diet: a review of the food monitoring and epidemiology data. Environmental Health. 2014;13:43. doi:10.1186/1476-069X-13-43. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050989/[↩][↩][↩][↩]
- Agency for Toxic Substances and Disease Registry (ATSDR). 2001. Toxicological Profile for Di-n-butyl Phthalate. Update. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. https://www.atsdr.cdc.gov/toxprofiles/tp135.pdf[↩]
- Sathyanarayana, S. 2008. Phthalates and children’s health. Current Problems in Pediatric and Adolescent Health Care 38 (2):34-49.[↩][↩]
- Kwapniewski, R., S. Kozaczka, R. Hauser, M.J. Silva, A.M. Calafat, and S.M. Duty. 2008. Occupational exposure to dibutyl phthalate among manicurists. Journal of Occupational and Environmental Medicine 50 (6):705-11.[↩]
- Temporal trends in phthalate exposures: findings from the National Health and Nutrition Examination Survey, 2001-2010. Zota AR, Calafat AM, Woodruff TJ. Environ Health Perspect. 2014 Mar; 122(3):235-41.[↩][↩]
- Phthalates and children’s health. Sathyanarayana S. Curr Probl Pediatr Adolesc Health Care. 2008 Feb; 38(2):34-49.[↩]
- Colacino, J.A., T.R. Harris, and A. Schecter. 2010. Dietary intake is associated with phthalate body burden in a nationally representative sample. Environmental Health Perspectives 118 (7):998-1003.[↩]
- Agency for Toxic Substances and Disease Registry (ATSDR). 2002. Toxicological Profile for Di(2-ethylhexyl)phthalate (DEHP). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. http://www.atsdr.cdc.gov/toxprofiles/tp9.pdf[↩][↩]
- Mortensen, G.K., K.M. Main, A.M. Andersson, H. Leffers, and N.E. Skakkebaek. 2005. Determination of phthalate monoesters in human milk, consumer milk, and infant formula by tandem mass spectrometry (LC-MS-MS). Anal Bioanal Chem 382 (4):1084-92.[↩]
- U.S. Environmental Protection Agency. 2008. Child-specific Exposure Factors Handbook (Final Report). Washington, DC: U.S. Environmental Protection Agency. EPA/600/R-06/096F.[↩]
- Calafat, A.M., and R.H. McKee. 2006. Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study. Environmental Health Perspectives 114 (11):1783-9.[↩]
- Otake, T., J. Yoshinaga, and Y. Yanagisawa. 2004. Exposure to phthalate esters from indoor environment. Journal of Exposure Analysis and Environmental Epidemiology 14 (7):524-8.[↩]
- Romero-Franco, M., R.U. Hernandez-Ramirez, A.M. Calafat, M.E. Cebrian, L.L. Needham, S. Teitelbaum, M.S. Wolff, and L. Lopez-Carrillo. 2011. Personal care product use and urinary levels of phthalate metabolites in Mexican women. Environment International 37 (5):867-71.[↩]
- Weuve, J., B.N. Sanchez, A.M. Calafat, T. Schettler, R.A. Green, H. Hu, and R. Hauser. 2006. Exposure to phthalates in neonatal intensive care unit infants: urinary concentrations of monoesters and oxidative metabolites. Environmental Health Perspectives 114 (9):1424-31.[↩]
- Silva, M.J., D.B. Barr, J.A. Reidy, N.A. Malek, C.C. Hodge, S.P. Caudill, J.W. Brock, L.L. Needham, and A.M. Calafat. 2004. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environmental Health Perspectives 112 (3):331-8.[↩][↩][↩]
- Diamanti-Kandarakis, E., J.P. Bourguignon, L.C. Giudice, R. Hauser, G.S. Prins, A.M. Soto, R.T. Zoeller, and A.C. Gore. 2009. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocrine Reviews 30 (4):293-342.[↩][↩]
- Christiansen, S., J. Boberg, M. Axelstad, M. Dalgaard, A.M. Vinggaard, S.B. Metzdorff, and U. Hass. 2010. Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats. Reproductive Toxicology 30 (2):313-21.[↩]
- Swan, S.H., K.M. Main, F. Liu, S.L. Stewart, R.L. Kruse, A.M. Calafat, C.S. Mao, J.B. Redmon, C.L. Ternand, S. Sullivan, et al. 2005. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environmental Health Perspectives 113 (8):1056-61.[↩]
- Macleod, D.J., R.M. Sharpe, M. Welsh, M. Fisken, H.M. Scott, G.R. Hutchison, A.J. Drake, and S. van den Driesche. 2010. Androgen action in the masculinization programming window and development of male reproductive organs. International Journal of Andrology 33 (2):279-87.[↩]
- Mendiola, J., R.W. Stahlhut, N. Jorgensen, F. Liu, and S.H. Swan. 2011. Shorter anogenital distance predicts poorer semen quality in young men in Rochester, New York. Environmental Health Perspectives 119 (7):958-63.[↩]
- Main, K.M., G.K. Mortensen, M.M. Kaleva, K.A. Boisen, I.N. Damgaard, M. Chellakooty, I.M. Schmidt, A.M. Suomi, H.E. Virtanen, D.V. Petersen, et al. 2006. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environmental Health Perspectives 114 (2):270-6.[↩]
- Miodovnik, A., S.M. Engel, C. Zhu, X. Ye, L.V. Soorya, M.J. Silva, A.M. Calafat, and M.S. Wolff. 2011. Endocrine disruptors and childhood social impairment. Neurotoxicology 32 (2):261-7.[↩]
- Cho, S.C., S.Y. Bhang, Y.C. Hong, M.S. Shin, B.N. Kim, J.W. Kim, H.J. Yoo, I.H. Cho, and H.W. Kim. 2010. Relationship between environmental phthalate exposure and the intelligence of school-age children. Environmental Health Perspectives 118 (7):1027-32.[↩]
- Whyatt, R.M., J.J. Adibi, A.M. Calafat, D.E. Camann, V. Rauh, H.K. Bhat, F.P. Perera, H. Andrews, A.C. Just, L. Hoepner, et al. 2009. Prenatal Di(2-ethylhexyl) phthalate exposure and length of gestation among an inner-city cohort. Pediatrics 124 (6):e1213-20.[↩]
- Adibi, J.J., R. Hauser, P.L. Williams, R.M. Whyatt, A.M. Calafat, H. Nelson, R. Herrick, and S.H. Swan. 2009. Maternal urinary metabolites of Di-(2-Ethylhexyl) phthalate in relation to the timing of labor in a US multicenter pregnancy cohort study. American Journal of Epidemiology 169 (8):1015-24.[↩]
- Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men. Joensen UN, Frederiksen H, Blomberg Jensen M, Lauritsen MP, Olesen IA, Lassen TH, Andersson AM, Jørgensen N. Environ Health Perspect. 2012 Oct; 120(10):1397-403.[↩]
- Phthalates and risk of endometriosis. Upson K, Sathyanarayana S, De Roos AJ, Thompson ML, Scholes D, Dills R, Holt VL. Environ Res. 2013 Oct; 126():91-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905445/[↩]
- Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002. Hatch EE, Nelson JW, Qureshi MM, Weinberg J, Moore LL, Singer M, Webster TF. Environ Health. 2008 Jun 3; 7():27.[↩]
- Chemical Listed Effective December 20, 2013 as Known to the State of California to Cause Cancer: Diisononyl Phthalate (DINP). https://oehha.ca.gov/proposition-65/crnr/chemical-listed-effective-december-20-2013-known-state-california-cause-cancer[↩]
- Jaakkola, J.J., and T.L. Knight. 2008. The role of exposure to phthalates from polyvinyl chloride products in the development of asthma and allergies: a systematic review and meta-analysis. Environmental Health Perspectives 116 (7):845-53.[↩]
- Bornehag, C.G., J. Sundell, C.J. Weschler, T. Sigsgaard, B. Lundgren, M. Hasselgren, and L. Hagerhed-Engman. 2004. The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Environmental Health Perspectives 112 (14):1393-7.[↩][↩][↩]
- Jaakkola, J.J., L. Oie, P. Nafstad, G. Botten, S.O. Samuelsen, and P. Magnus. 1999. Interior surface materials in the home and the development of bronchial obstruction in young children in Oslo, Norway. American Journal of Public Health 89 (2):188-92.[↩]
- All About Phthalates. https://www.niehs.nih.gov/research/supported/translational/peph/podcasts/phthalates/index.cfm[↩]
- National Toxicology Program. 2006. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-Ethylhexyl) Phthalate (DEHP), edited by U.S. Department of Health and Human Services. Research Triangle Park, NC: NIH.[↩]
- Huang, P.C., P.L. Kuo, Y.L. Guo, P.C. Liao, and C.C. Lee. 2007. Associations between urinary phthalate monoesters and thyroid hormones in pregnant women. Human Reproduction 22 (10):2715-22.[↩]
- Identifying sources of phthalate exposure with human biomonitoring: results of a 48h fasting study with urine collection and personal activity patterns. Koch HM, Lorber M, Christensen KL, Pälmke C, Koslitz S, Brüning T. Int J Hyg Environ Health. 2013 Nov; 216(6):672-81. https://www.ncbi.nlm.nih.gov/pubmed/23333758/[↩]
- Cao X. Phthalate esters in foods: sources, occurrence, and analytical methods. Compr Rev Food Sci Food Saf. 2010;9:21–43. doi: 10.1111/j.1541-4337.2009.00093.x[↩][↩]
- Indirect food additives: polymers. Indirect food additives: polymers”. Title 21 Code of Federal Regulations; 2014. Part 177.[↩]
- Phthalates and food-contact materials: enforcing the 2008 European Union plastics legislation. Petersen JH, Jensen LK. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Nov; 27(11):1608-16.[↩]
- Phthalate concentrations and dietary exposure from food purchased in New York State. Schecter A, Lorber M, Guo Y, Wu Q, Yun SH, Kannan K, Hommel M, Imran N, Hynan LS, Cheng D, Colacino JA, Birnbaum LS. Environ Health Perspect. 2013 Apr; 121(4):473-94.[↩]
- Phthalates dietary exposure and food sources for Belgian preschool children and adults. Sioen I, Fierens T, Van Holderbeke M, Geerts L, Bellemans M, De Maeyer M, Servaes K, Vanermen G, Boon PE, De Henauw S. Environ Int. 2012 Nov 1; 48():102-8.[↩]
- Estimation of dietary intake of bis(2-ethylhexyl)phthalate (DEHP) by consumption of food in the German population. Heinemeyer G, Sommerfeld C, Springer A, Heiland A, Lindtner O, Greiner M, Heuer T, Krems C, Conrad A. Int J Hyg Environ Health. 2013 Jul; 216(4):472-80.[↩]
- Phthalates Exposures through Diet: Lessons Learned. NIEHS/EPA: Children’s Health Environmental Health Research Centers Webinars. June 10, 2015. https://www.epa.gov/sites/production/files/2016-11/documents/cehc_june2015_sathyanarayana.pdf[↩]
- Phthalate exposure through food and consumers’ risk perception of chemicals in food. Dickson-Spillmann M, Siegrist M, Keller C, Wormuth M. Risk Anal. 2009 Aug; 29(8):1170-81.[↩]
- Ji K, Kho YL, Park Y, Choi K. Influence of a five-day vegetarian diet on urinary levels of antibiotics and phthalate metabolites: A pilot study with “Temple Stay” participants. Environ Res. 2010;110:375–382. doi: 10.1016/j.envres.2010.02.008.[↩][↩]
- What are the sources of exposure to eight frequently used phthalic acid esters in Europeans? Wormuth M, Scheringer M, Vollenweider M, Hungerbühler K. Risk Anal. 2006 Jun; 26(3):803-24.[↩]
- Colacino JA, Harris TR, Schecter A. Dietary intake is associated with phthalate body burden in a nationally representative sample. Environ Health Perspect. 2010;118:998–1003. doi: 10.1289/ehp.0901712[↩]
- Trasande L, Sathyanarayana S, Messito MJ, Gross RS, Attina TM, Mendelsohln AL. Phthalates and the diets of US children and adolescents. Environ Res. 2013;126:84–90[↩]
- Dickson-Spillmann M, Siegrist M, Keller C, Wormuth M. Phthalate exposure through food and consumers’ risk perception of chemicals in food. Risk Anal. 2009;29(8):1170–1181. doi: 10.1111/j.1539-6924.2009.01233.x[↩]
- Ji K, Kho YL, Park Y, Choi K. Influence of a five-day vegetarian diet on urinary levels of antibiotics and phthalate metabolites: A pilot study with “Temple Stay” participants. Environ Res. 2010;110:375–382. doi: 10.1016/j.envres.2010.02.008[↩]
- Phthalates. https://www.fda.gov/Cosmetics/ProductsIngredients/Ingredients/ucm128250.htm[↩][↩][↩][↩]
- Annual Review of Cosmetic Ingredient Safety Assessments 2002/2003. International Journal of Toxicology (Supplement 1), 1-102, 2005.[↩][↩][↩][↩]
- Phthalates Factsheet. https://www.cdc.gov/biomonitoring/phthalates_factsheet.html[↩]
- Baby Care Products: Possible Sources of Infant Phthalate Exposure,” disclaimer icon S. Sathyanarayana, Pediatrics, 2008, vol. 121, pp. 260-268[↩]