What is shingles

Anyone who has had chickenpox (varicella-zoster virus infection) can get shingles. Varicella-zoster virus is also called herpesvirus 3 and is a member of the Herpesvirales order of double-stranded DNA viruses. Shingles is a varicella-zoster virus infection (also known as zoster or herpes zoster) that reactivates (wakes up) causing a painful rash, blistering rash. Most cases of chickenpox occur in children under age 15, but older children and adults can get it too. Chickenpox (varicella-zoster virus infection) spreads very easily from one person to another. After the chickenpox clears, the varicella-zoster virus stays inside your body (inside the nerves and lie dormant for years). The varicella-zoster virus may not cause problems for many years. Eventually, it may reactivates (wakes up) and travels along nerve pathways to your skin — producing shingles — a painful, blistering rash. But, not everyone who’s had chickenpox will develop shingles. Shingles tends to cause more pain and less itching than chickenpox. As you get older, the varicella-zoster virus may reappear as shingles. Although shingles is most common in people over age 50, anyone who has had chickenpox is at risk.

Almost 1 out of every 3 people in the United States will develop shingles, also known as herpes zoster, in their lifetime. There are an estimated 1 million cases of shingles each year in this country. Anyone who has recovered from chickenpox may develop shingles; even children can get shingles. However, the risk of shingles increases as you get older. About half of all cases occur in people 60 years old or older.

There is no cure for shingles. Early treatment with medicines that fight the virus may help. These medicines may also help prevent lingering pain.

• If you think you might have shingles, talk to your doctor as soon as possible. It’s important to see your doctor no later than 3 days after the rash starts. The doctor will confirm whether or not you have shingles and can make a treatment plan. Although there is no cure for shingles, early treatment with drugs that fight the virus can help the blisters dry up faster and limit severe pain. Shingles can often be treated at home. People with shingles rarely need to stay in a hospital.

The risk of getting shingles increases with age. A vaccine can reduce your risk of getting shingles or lessen its effects. Your doctor may recommend getting this vaccine after your 50th birthday or once you reach 60 years of age. There’s another — and maybe even more important — reason for getting the shingles vaccine. If you’ve had chickenpox, you can still get shingles after getting shingles vaccine. The vaccine also lessens your risk of developing serious complications from shingles, such as life-disrupting nerve pain.

The nerve pain can last long after the shingles rash goes away. Some people have this nerve pain, called post-herpetic neuralgia (PHN), for many years. The pain can be so bad that it interferes with your everyday life. The shingles vaccine reduces your risk of developing this nerve pain, even more than it reduces your risk of getting shingles.

An anti-viral medicine may also prevent long-lasting nerve pain if your get shingles. It’s most effective when started within 3 days of seeing the rash. The anti-viral medicine can also make shingles symptoms milder and shorter.

Protect Yourself Against Shingles

Adults 60 years old or older should talk to their healthcare professional about getting a one-time dose of the shingles vaccine.

• The shingles vaccine can reduce your risk of shingles and the long-term pain it can cause ¹⁾.
• Persons who have already had shingles or who have a chronic medical condition can receive the shingles vaccine.
• In a clinical trial involving thousands of adults 60 years old or older, the vaccine reduced the risk of shingles by about half. Even if the shingles vaccine doesn’t prevent you from getting shingles, it can still reduce the chance of having long-term pain or post-herpetic neuralgia.

Talk with your healthcare professional for more information and to find out if the shingles vaccine is right for you.

Adults can get vaccines at doctors’ offices, pharmacies, workplaces, community health clinics, and health departments. To find a place to get a vaccine near you, go to https://vaccinefinder.org/

Most private health insurance plans cover recommended vaccines. Check with your insurance provider for details and for a list of vaccine providers. Medicare Part D plans cover shingles vaccine, but there may be costs to you depending on your specific plan.

If you do not have health insurance, visit https://www.healthcare.gov/ to learn more about health insurance options.

Complications of shingles

The most common complication of shingles is a condition called post-herpetic neuralgia (PHN). People with post-herpetic neuralgia have severe pain in the areas where they had the shingles rash, even after the rash clears up. Post-herpetic neuralgia is diagnosed in people who have pain that persists after their rash has resolved. Some define post-herpetic neuralgia as any duration of pain after the rash resolves; others define it as duration of pain for more than 30 days, or for more than 90 days after rash onset.

The pain from post-herpetic neuralgia may be severe and debilitating, but it usually resolves in a few weeks or months. Some people can have pain from post-herpetic neuralgia for many years and can interfere with daily life.

A person’s risk of having post-herpetic neuralgia after herpes zoster increases with age. As people get older, they are more likely to develop post-herpetic neuralgia, and the pain is more likely to be severe. Post-herpetic neuralgia occurs rarely among people under 40 years of age but can occur in approximately 13% (and possibly more) of untreated people who are 60 years of age and older with herpes zoster. Older adults are more likely to have post-herpetic neuralgia and to have longer lasting and more severe pain. Other predictors of post-herpetic neuralgia include the level of pain a person has when they have the rash and the size of their rash.

Other complications of herpes zoster include:

• Shingles may also lead to serious complications involving the eye (herpes zoster ophthalmicus) may result in vision loss.
• Bacterial superinfection of the lesions, usually due to Staphylococcus aureus and, less commonly, due to group A beta hemolytic streptococcus.
• Cranial and peripheral nerve palsies. Depending on which nerves are affected, shingles can cause an inflammation of the brain (encephalitis), facial paralysis, or hearing or balance problems.
• Very rarely, shingles can also lead to pneumonia, hearing problems, blindness, brain inflammation (meningoencephalitis), hepatitis, acute retinal necrosis or death.

People with compromised or suppressed immune systems are more likely to have complications from herpes zoster. They are more likely to have severe rash that lasts longer. Also, they are at increased risk of developing disseminated herpes zoster.

What does shingles look like

Shingles or Herpes zoster is a localized, blistering and painful rash caused by reactivation of varicella zoster virus (VZV). It is characterized by dermatomal distribution (Dermatome see Figure 6 below), that is the blisters are confined to the cutaneous distribution of one or two adjacent sensory nerves.

The distribution of shingles refers to how the skin lesions are scattered or spread out. The localization of multiple lesions in certain regions helps diagnosis, as shingles tend to have characteristic distributions.

Figure 1. Shingles rash (blisters) – the typical early onset of herpes zoster (shingles) includes blisters in groups. The blisters often have a central depression.

Figure 2. Shingles rash body – typical of zoster (shingles), these images display grouped blisters with central depressions in a red, band-like distribution.

Figure 3. Shingles rash

Figure 4. Shingles on face

Note: If blisters appear on the tip of your nose, it may be a warning of possible eye problems. Shingles that involve the eye are called ocular shingles or herpes zoster ophthalmicus. Signs and symptoms of shingles in the eye are blisters around the eye or on the eyelid, swelling and redness of the eye or eyelid, and eye pain. Some people become sensitive to light. After a bout with shingles that involves the eye, a person can have blurred vision or feel that something is in the eye.

Anyone who gets blisters on the nose should see a doctor immediately. Without treatment, permanent eye damage can result. Glaucoma, scarring, and even blindness are possible. People who have shingles in the eye also may have a higher risk for having a stroke.

Figure 5. Shingles in the eye

Note: Shingles rash along the face or brow area may involve the eye. The varicella-zoster virus can travel through the nerve fibers and emerge in the cornea. Eye pain, redness, tearing, and blurring are common symptoms of ocular shingles. If this happens, your eye care professional may prescribe oral anti­-viral treatment to reduce the risk of inflammation and scarring in the cornea. Shingles can also cause decreased sensitivity in the cornea. Corneal problems may arise months after the shingles are gone from the rest of the body. If you experience shingles in your eye, or nose, or on your face, it’s important to have your eyes examined several months after the shingles have cleared. If left untreated, this infection can lead to permanent eye damage.

Figure 6. Dermatome (spinal nerves sensory innvervation)

Note: The skin over the entire body is supplied by somatic sensory neurons that carry nerve impulses from the skin into the spinal cord and brain. Each spinal nerve contains sensory neurons that serve a specific, predictable segment of the body. One of the cranial nerves, the Trigeminal (V) nerve, serves most of the skin of the face and scalp. The area of the skin that provides sensory input to the central nervous system (CNS) via one pair of spinal nerves or the Trigeminal (V) nerve is called a dermatome. The varicella zoster virus lie dormant inside these nerves and only to be reactivated and travel along the nerve pathways to your skin — producing shingles — a painful, blistering rash.

What causes shingles

Shingles is caused by the varicella zoster virus, the same virus that causes chickenpox. After a person recovers from chickenpox, the virus stays dormant (inactive) in the body. Shingles appears when the virus wakes up. Scientists aren’t sure why the virus can reactivates or “wakes up” years later, causing shingles. A short-term weakness in immunity may cause this.

Shingles cannot be passed from one person to another. However, the virus that causes shingles, the varicella zoster virus, can spread from a person with active shingles to cause chickenpox in someone who had never had chickenpox or received chickenpox vaccine.

The virus is spread through direct contact with fluid from the rash blisters caused by shingles.

A person with active shingles can spread the virus when the rash is in the blister-phase. A person is not infectious before the blisters appear. Once the rash has developed crusts, the person is no longer infectious.

Shingles is less contagious than chickenpox and the risk of a person with shingles spreading the virus is low if the rash is covered.

If you have shingles, you should:

• Cover the rash.
• Avoid touching or scratching the rash.
• Wash your hands often to prevent the spread of varicella zoster virus.
• Avoid contact with the people below until your rash has developed crusts
  • pregnant women who have never had chickenpox or the chickenpox vaccine;
  • premature or low birth weight infants; and
  • people with weakened immune systems, such as people receiving immunosuppressive medications or undergoing chemotherapy, organ transplant recipients, and people with human immunodeficiency virus (HIV) infection.

Risk factors for shingles

Anyone who has ever had chickenpox can develop shingles. Most adults in the United States had chickenpox when they were children, before the advent of the routine childhood vaccination that now protects against chickenpox.

Factors that may increase your risk of developing shingles include:

• Being older than 50. Shingles is most common in people older than 50. The risk increases with age. Some experts estimate that half the people age 80 and older will have shingles.
• Having certain diseases. Diseases that weaken your immune system, such as HIV/AIDS and cancer, can increase your risk of shingles.
• Undergoing cancer treatments. Radiation or chemotherapy can lower your resistance to diseases and may trigger shingles.
• Taking certain medications. Drugs designed to prevent rejection of transplanted organs can increase your risk of shingles — as can prolonged use of steroids, such as prednisone.

Shingles symptoms

Early signs of shingles include burning or shooting pain and tingling or itching, usually on one side of the body or face. The most common place for shingles is a band that goes around one side of your waistline. The pain can be mild to severe. Rashes or blisters appear anywhere from one to 14 days later. The rash consists of blisters that typically scab over in 7 to 10 days. The rash usually clears up within 2 to 4 weeks. If shingles appears on your face, it may affect your vision or hearing. The pain of shingles may last for weeks, months, or even years after the blisters have healed.

The warning: Before the rash develops, people often have pain, itching, burning or tingling in the area where the rash will develop. And area of skin may feel very sensitive. This usually occurs in a small area on 1 side of the body. These symptoms can come and go or be constant. Most people experience this for 1 to 5 days before the rash appears. It can last longer.

Rash: A rash then appears in the same area. Most commonly, the rash occurs in a single stripe around either the left or the right side of the body. In other cases, the rash occurs on one side of the face. In rare cases (usually among people with weakened immune systems), the rash may be more widespread and look similar to a chickenpox rash. Shingles can affect the eye and cause loss of vision.

Blisters: The rash soon turns into groups of clear blisters. The blisters turn yellow or bloody before they crust over (scab) and heal. The blisters tend to last 2 to 3 weeks.

Pain: It is uncommon to have blisters without pain. Once the blisters heal, the pain tends to lessen. The pain can last for months after the blisters clear.

Flu-like symptoms: The person may get a fever, headache, chills or upset stomach with the rash.

How Long Does Shingles Last?

Most cases of shingles last 3 to 5 weeks. Shingles follows a pattern:

• The first sign is often burning or tingling pain; sometimes, it includes numbness or itching on one side of the body.
• Somewhere between 1 and 5 days after the tingling or burning feeling on the skin, a red rash will appear.
• A few days later, the rash will turn into fluid-filled blisters.
• About a week to 10 days after that, the blisters dry up and crust over.
• A couple of weeks later, the scabs clear up.

Most people get shingles only one time. But, it is possible to have it more than once.

Long-Term Pain and Other Lasting Problems

After the shingles rash goes away, some people may be left with ongoing pain called post-herpetic neuralgia or PHN. The pain is felt in the area where the rash had been. For some people, post-herpetic neuralgia is the longest lasting and worst part of shingles. The older you are when you get shingles, the greater your chance of developing post-herpetic neuralgia.

The post-herpetic neuralgia pain can cause depression, anxiety, sleeplessness, and weight loss. Some people with post-herpetic neuralgia find it hard to go about their daily activities, like dressing, cooking, and eating. Talk with your doctor if you have any of these problems.

There are medicines that may help with post-herpetic neuralgia. Steroids may lessen the pain and shorten the time you’re sick. Analgesics, antidepressants, and anticonvulsants may also reduce the pain. Usually, post-herpetic neuralgia will get better over time.

Some people have other problems that last after shingles has cleared up. For example, the blisters caused by shingles can become infected. They may also leave a scar. It is important to keep the area clean and try not to scratch the blisters. Your doctor can prescribe an antibiotic treatment if needed.

See your doctor right away if you notice blisters on your face—this is an urgent problem. Blisters near or in the eye can cause lasting eye damage or blindness. Hearing loss, a brief paralysis of the face, or, very rarely, swelling of the brain (encephalitis) can also occur.

Prevention of shingles

Two vaccines may help prevent shingles — the chickenpox (varicella) vaccine and the shingles (varicella-zoster) vaccine.

Chickenpox vaccine

The varicella vaccine (Varivax) has become a routine childhood immunization to prevent chickenpox. The vaccine is also recommended for adults who’ve never had chickenpox. Though the vaccine doesn’t guarantee you won’t get chickenpox or shingles, it can reduce your chances of complications and reduce the severity of the disease.

Shingles vaccine

The Food and Drug Administration has approved the use of the varicella-zoster vaccine (Zostavax®) for adults age 50 and older, whether they’ve already had shingles or not. Although the vaccine is approved for people age 50 and older, the Centers for Disease Control and Prevention isn’t recommending it until you reach age 60 or older, when the risk of shingles and its complications is highest. Zostavax® was licensed by the FDA in 2006 for use in the United States. It is given in one dose as a shot, and can be given in a doctor’s office or pharmacy.

Your doctor may recommend vaccination between ages 50 and 59 if you have a condition or circumstance that may make it more difficult to tolerate a shingles infection, such as chronic pain or if you have received or expect to receive certain medications that suppress the immune system.

As with the chickenpox vaccine, the shingles vaccine doesn’t guarantee you won’t get shingles. But this vaccine will likely reduce the course and severity of the disease and reduce your risk of postherpetic neuralgia within the first five years after vaccination. Protection beyond five years is uncertain.

The shingles vaccine is used only as a prevention strategy. It’s not intended to treat people who currently have the disease. The vaccine contains live virus and should not be given to people who are pregnant or have weakened immune systems.

In October 2017, the U.S. Food and Drug Administration (FDA) ²⁾ approved a new vaccine, Shingrix®, that can prevent shingles for adults aged 50 years and older. This is the second vaccine that the FDA has approved to prevent shingles.

The Advisory Committee on Immunization Practices ³⁾ voted that Shingrix® is:

• recommended for healthy adults aged 50 years and older to prevent shingles and related complications
• recommended for adults who previously received the current shingles vaccine (Zostavax®) to prevent shingles and related complications
• the preferred vaccine for preventing shingles and related complications

Who Should Get Shingles Vaccine?

People 60 years of age or older should get shingles vaccine (Zostavax®). People 60 years of age or older should get the Zostavax® vaccine whether or not they recall having had chickenpox, which is caused by the same virus as shingles. Studies show that more than 99% of Americans aged 40 and older have had chickenpox, even if they don’t remember getting the disease. There is no maximum age for getting shingles vaccine.

• Zostavax®, the shingles vaccine, reduced the risk of shingles by 51% and the risk of post-herpetic neuralgia by 67% based on a large study of more than 38,000 adults aged 60 years or older. Protection from shingles vaccine lasts about 5 years.
• While the vaccine was most effective in people 60 through 69 years old, it also provides some protection for people 70 years old and older.
• Adults vaccinated before age 60 years might not be protected later in life when the risk for shingles and its complications are greatest.

Even if you have had shingles, you can still receive shingles vaccine to help prevent future occurrences of the disease. There is no specific length of time you must wait after having shingles before receiving shingles vaccine, but generally you should make sure the shingles rash has disappeared before getting vaccinated. The decision on when to get vaccinated should be made with your healthcare provider.

Zostavax® is approved by the Food and Drug Administration for people aged 50 years and older. However, Centers for Disease Control and Prevention (CDC) does not have a recommendation for routine use of Zostavax® in people 50 through 59 years old. Protection from this shingles vaccine lasts about 5 years, so adults vaccinated before they are 60 years old might not be protected later in life when the risk for shingles and its complications are greatest. Adults 50 through 59 years who have questions about shingles vaccine should discuss the risks and benefits with a healthcare provider.

Talk with your healthcare provider if you have questions about shingles vaccine. Shingles vaccine is available in doctor’s offices and pharmacies.

What Are the Possible Side Effects of Shingles Vaccine?

A vaccine, like any medicine, could possibly cause serious problems, such as severe allergic reactions. However, the risk of a vaccine causing serious harm, or death, is extremely small.

No serious problems have been identified with shingles vaccine.

Mild side effects of shingles vaccine:

• Redness, soreness, swelling, or itching at the site of the injection (about 1 person in 3).
• Headache (about 1 person in 70).

It is safe to be around infants and young children, pregnant women, or people with weakened immune systems after you get the shingles vaccine. There is no documentation of a person getting chickenpox from someone who has received the shingles vaccine (which contains varicella zoster virus).

Some people who get the shingles vaccine will develop a chickenpox-like rash near the place where they were vaccinated. As a precaution, this rash should be covered until it disappears.

Like all vaccines, shingles vaccine is being closely monitored for unusual or severe problems by CDC and FDA.

Signs of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. These would start a few minutes to a few hours after the vaccination. If you have a severe allergic reaction or other emergency that can’t wait, call your local emergency number or get the person to the nearest hospital. Otherwise, see your doctor.

Who Should Not Get Shingles Vaccine?

Some people should not get shingles vaccine (Zostavax) ⁴⁾:

• A person who has ever had a life-threatening or severe allergic reaction to gelatin, the antibiotic neomycin, or any other component of shingles vaccine. Tell your doctor if you have any severe allergies.
• A person who has a weakened immune system because of:
  • HIV/AIDS or another disease that affects the immune system,
  • treatment with drugs that affect the immune system, such as steroids,
  • cancer treatment such as radiation or chemotherapy, or
  • cancer affecting the bone marrow or lymphatic system, such as leukemia or lymphoma.
• Women who are or might be pregnant. Women should not become pregnant until at least 4 weeks after getting shingles vaccine.

Someone with a minor acute illness, such as a cold, may be vaccinated. But anyone with a moderate or severe acute illness should usually wait until they recover before getting the vaccine. This includes anyone with a temperature of 101.3°F or higher.

Diagnosis of shingles

Shingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory.

Shingles treatment

There’s no cure for shingles, but prompt treatment with prescription antiviral drugs can speed healing and reduce your risk of complications. These medications include:

• Acyclovir (Zovirax)
• Valacyclovir (Valtrex)

Management of acute herpes zoster may include:

• Rest and pain relief
• Protective ointment applied to the rash, such as petroleum jelly.
• Oral antibiotics for secondary infection

Shingles can cause severe pain, so your doctor also may prescribe:

• Capsaicin topical patch (Qutenza)
• Anticonvulsants, such as gabapentin (Neurontin)
• Tricyclic antidepressants, such as amitriptyline
• Numbing agents, such as lidocaine, delivered via a cream, gel, spray or skin patch
• Medications that contain narcotics, such as codeine
• An injection including corticosteroids and local anesthetics

Shingles generally lasts between two and six weeks. Most people get shingles only once, but it is possible to get it two or more times.

Shingles medication

It is best to get treatment immediately. Treatment can include:

Pain relievers to help ease the pain: The pain can be very bad, and prescription painkillers may be necessary.

Post-herpetic neuralgia may be difficult to treat successfully. It may respond to any of the following.

• Local anesthetic applications
• Topical capsaicin
• Tricyclic antidepressant medications such as amitriptyline
• Anti-epileptic medications gabapentin and pregabalin
• Transcutaneous electrical nerve stimulation or acupuncture
• Botulinum toxin into the affected area

Nonsteroidal anti-inflammatories (NSAIDs) and opioids are generally unhelpful.

Anti-viral medicine: This medicine may be prescribed when a doctor diagnoses shingles within 72 hours of the rash first appearing. The earlier anti-viral treatment is started, the better it works. Anti-viral medicines include famciclovir, valacyclovir, and acyclovir. These can lessen the pain and the amount of time the pain lasts.

Nerve blocks: Given for intense pain, these injections (shots) contain a numbing anesthetic and sometimes a corticosteroid.

Corticosteroids: To lower swelling and pain, some patients may get corticosteroid pills with their anti-viral medicine. This treatment is not common because it can make the rash spread.

Treatments for pain after the rash clears: Certain anti-depressants, pain relievers, anesthetic creams and patches, and anti-seizure medicines can help.

Home remedies for shingles

• Get plenty of rest and eat well-balanced meals.
• Try simple exercises like stretching or walking. Check with your doctor before starting a new exercise routine.
• Apply a cool washcloth to your blisters to ease the pain and help dry the blisters.
• Cool compresses, baths or ice packs may help with the discomfort. Do not apply ice packs directly to the skin. Wrap the ice pack in a light towel and place it gently over the dressing. Wash the towel in hot water after use.
• Apply calamine lotion to the blisters.
• Cover the rash with loose, non-stick, sterile bandages.
• Wear loose cotton clothes around the body parts that hurt.
• Do things that take your mind off your pain. For example, watch TV, read, talk with friends, listen to relaxing music, or work on a hobby you like.
• Avoid stress. It can make the pain worse.
• Try not to scratch the rash. Scratching may cause scarring and infection of the blisters.
• If the blisters are open, applying creams or gels is not recommended because they might increase the risk of a secondary bacterial infection.
• After a bath or shower, gently pat yourself dry with a clean towel. Do not rub or use the towel to scratch yourself and do not share towels.
• Do not use antibiotic creams or sticking plasters on the blisters since they may slow down the healing process.
• Take an oatmeal bath or use calamine lotion to see if it soothes your skin.
• Avoid contact with people who may be more at risk, such as pregnant women who are not immune to chickenpox, people who have a weak immune system and babies less than 1 month old.
• Do not share towels, play contact sports, or go swimming.
• Share your feelings about your pain with family and friends. Ask for their understanding.

Also, you can limit spreading the virus by:

• Keeping the rash covered
• Not touching or scratching the rash
• Washing your hands often