What is cinnamon
Cinnamon (Cinnamomum zeylanicum and Cinnamon cassia) is a spice obtained from the inner bark of several tree species from the genus Cinnamomum that belongs to the Lauraceae family 1). Used as a spice for thousands of years, cinnamon comes from the bark of the cinnamon tree. Preparation of cinnamon involves stripping of the outer bark of the tree and letting the inner bark to dry and curl up into its customary cinnamon quills. Cinnamon is available in either its whole quill form (Cinnamon sticks) or as ground powder in the market 2). The aromatic bark of the various cinnamon species tree is used worldwide for culinary purposes, but is also used in Ayurvedic and traditional Chinese medicine for its hypoglycaemic, digestive, antispasmodic and antiseptic properties 3), 4). Overall, approximately 300 species have been identified among the cinnamon genus, with trees being scattered all over the world 5), 6). Cassia cinnamon, native to China, is the most common type sold in the United States and Canada. Ceylon cinnamon (Cinnamomum verum or Cinnamomum zeylanicum), native to Sri Lanka, is common in other countries and is known as “true” cinnamon 7). Indonesia (Cinnamomum burmanii) and China (Cinnamomum cassia) contribute 76% of the world’s production of cinnamon 8). Essential oils are made from the bark, leaves, or twigs of cassia cinnamon.
Cinnamon is mainly used in the aroma and essence industries due to its fragrance, which can be incorporated into different varieties of foodstuffs, perfumes, and medicinal products 9). The most important constituents of cinnamon are cinnamaldehyde and trans-cinnamaldehyde (Cin), which are present in the essential oil, thus contributing to the fragrance and to the various biological activities observed with cinnamon 10). A study on Cinnamomum osmophloeum (C. osmophloeum) indicated that the essential oil from cinnamon leaves contains a high level of trans-cinnamaldehyde (Cin). Consequently, Cinnamomum osmophloeum is also used as an alternative spice for cinnamon cassia 11). One of the major constituents of essential oil extracted from Cinnamomum zeylanicum named (E)-cinnamaldehyde has an antityrosinase activity 12), while cinnamaldehyde is the principal compound responsible for this activity 13).
Cinnamon bark contains procyanidins and catechins 14). The components of procyanidins include both procyanidin A-type and B-type linkages 15). These procyanidins extracted from cinnamon and berries also possess antioxidant activities 16).
Cinnamon has a long history as a traditional medicine, including for bronchitis. Today, some people use cinnamon as a dietary supplement for gastrointestinal problems, loss of appetite, and diabetes, among other conditions. Cinnamon is used in capsules, teas, and extracts.
However, studies done in humans don’t support using cinnamon for any health condition 17), 18), 19). A 2013 systematic review 20) of 10 randomized controlled clinical trials in people with type 1 or type 2 diabetes suggests that cinnamon doesn’t help to reduce levels of glucose or glycosylated hemoglobin A1c (HbA1c), a long-term measure of glucose (blood sugar) control. A 2012 Cochrane systematic review 21) of 10 randomized controlled trials involving a total of 577 participants found insufficient evidence to support the use of cinnamon for type 1 or type 2 diabetes. A product containing cinnamon, calcium, and zinc didn’t improve blood pressure in a small study of people with type 2 diabetes 22).
Traditional uses of cinnamon
In addition to being used as a spice and flavoring agent, cinnamon is also added to flavor chewing gums due to its mouth refreshing effects and ability to remove bad breath 23). Cinnamon can also improve the health of the colon, thereby reducing the risk of colon cancer 24).
Cinnamon is a coagulant and prevents bleeding 25). Cinnamon also increases the blood circulation in the uterus and advances tissue regeneration 26). This plant plays a vital role as a spice, but its essential oils and other constituents also have important activities, including antimicrobial 27), antifungal 28), antioxidant 29), and antidiabetic 30).
Cinnamon has been used as anti-inflammatory 31), antitermitic 32), nematicidal 33), mosquito larvicidal 34), insecticidal 35), antimycotic 36) and anticancer agent 37). Cinnamon has also been traditionally used as tooth powder and to treat toothaches, dental problems, oral microbiota, and bad breath 38). At present Cinnamon is sold as both a preventative and therapeutic supplement for many ailments including, metabolic syndrome, insulin resistance, type 2 diabetes, hyperlipidaemia and arthritis 39).
Note: All of the traditional uses outlined above have not be proven by well conducted scientific randomized clinical studies in human. Most of the traditional uses of cinnamon have all be done in laboratory test tubes and using animals as test subjects. We only list them here only to show what ailments and treatments cinnamon has been used traditionally and not because cinnamon has been proven to work in humans. More research are required before their benefits in human can be confirmed. Until larger and more rigorous clinical studies are available on the safety and efficacy of cinnamon as well as the feasibility of it as a component of integrative medicine, we recommend that patients continue to follow existing recommendations from their health care professionals.
Cinnamon nutrition facts
Almost every part of the cinnamon tree including the bark, leaves, flowers, fruits and roots, has some medicinal or culinary use. The volatile oils obtained from the bark, leaf, and root barks vary significantly in chemical composition, which suggests that they might vary in their pharmacological effects as well 40). The different parts of the plant possess the same array of hydrocarbons in varying proportions, with primary constituents such as; cinnamaldehyde (bark), eugenol (leaf) and camphor (root) 41). Thus cinnamon offers an array of different oils with diverse characteristics, each of which determines its’ value to the different industries. For example the root which has camphor as the main constitute, has minimal commercial value unlike the leaf and bark 42). It is this chemical diversity that is likely to be the reason for the wide-variety of medicinal benefits observed with cinnamon.
Table 1. Ground cinnamon nutrition content
Value per 100 g
tsp 2.6 g
tbsp 7.8 g
|Total lipid (fat)||g||1.24||0.03||0.10|
|Carbohydrate, by difference||g||80.59||2.10||6.29|
|Fiber, total dietary||g||53.1||1.4||4.1|
|Vitamin C, total ascorbic acid||mg||3.8||0.1||0.3|
|Vitamin A, RAE||µg||15||0||1|
|Vitamin A, IU||IU||295||8||23|
|Vitamin E (alpha-tocopherol)||mg||2.32||0.06||0.18|
|Vitamin D (D2 + D3)||µg||0.0||0.0||0.0|
|Vitamin K (phylloquinone)||µg||31.2||0.8||2.4|
|Fatty acids, total saturated||g||0.345||0.009||0.027|
|Fatty acids, total monounsaturated||g||0.246||0.006||0.019|
|Fatty acids, total polyunsaturated||g||0.068||0.002||0.005|
|Fatty acids, total trans||g||0.000||0.000||0.000|
Table 2. Chemical constituents of different parts of cinnamon
|Part of the plant||Compound|
|Leaves||Cinnamaldehyde: 1.00 to 5.00%|
|Eugenol: 70.00 to 95.00%|
|Bark||Cinnamaldehyde: 65.00 to 80.00%|
|Eugenol: 5.00 to 10.00%|
|Root bark||Camphor: 60.00%|
|Fruit||trans-Cinnamyl acetate (42.00 to 54.00%)|
and caryophyllene (9.00 to 14.00%)
|C. zeylanicum buds||Terpene hydrocarbons: 78.00%|
|Oxygenated terpenoids: 9.00%|
|C. zeylanicum flowers||(E)-Cinnamyl acetate: 41.98%|
|Caryophyllene oxide: 7.20%|
Health benefits of cinnamon
Studies have been consistent in showing that diabetic patient adherence to current conventional treatment protocols are poor 45). Diabetic patients are 1.6 times more likely than non-diabetics to use a complementary and alternative medicine for a host of reasons 46). The worldwide trend for the use of complementary and alternative medicines in diabetes has increased with an overall prevalence ranging between 30-57 % 47).
Recent estimates show that over 80 % of people living in developing countries depend on complementary and alternative medicine for treatment of health conditions 48). More recently in 2013, Herman estimates the cost of Complementary and Integrative Medicine in the US to be 34 billion dollars 49).
Cinnamon has been a research interest in patients with diabetes since the 1990s 50). Various data from randomized clinical trials show conflicting results of the effects of cinnamon on glycemic and lipid parameters. Consumption of 1 to 1.2 g/d was associated with an increase in fasting plasma glucose levels 51), 52) and hemoglobin A1c levels 53), 54); however, others have reported reductions in glycemic parameters at doses between 1 to 6 g/d 55), 56), 57) and in hemoglobin A1c 58), 59), 60). The same conflict occurs in lipid parameters, at 1 g/d total cholesterol 61), LDL-“bad” Cholesterol 62), 63) and triglyceride levels were reported to increase 64), while HDL-“good” Cholesterol levels decreased 65), 66). Only 1 trial identified statistically significant increases in hemoglobin A1c and fasting plasma glucose levels; however, this trial was published only as a research brief, so many of the study characteristics were unclear 67). Based on currently available literature, cinnamon may have a beneficial effect on fasting plasma glucose, LDL-“bad” Cholesterol, HDL-“good” Cholesterol and triglyceride levels in patients with type 2 diabetes 68). But there is no statistically significant effect on hemoglobin A1c (HbA1c). Contrary to the finding of this study, a Cochrane Review 69) involving oral monopreparations of cinnamon (primarily Cinnamomum cassia) in tablet or capsule form, at an average daily dose of 2 g, for a mean period of 11 weeks, found that in people with type 1 or type 2 diabetes mellitus, orally administered cinnamon (Cinnamomum cassia) in tablet or capsule form, at a dose of 0.5 to 6 g daily for a period of four to 16 weeks, is no more effective than placebo at improving glycosylated haemoglobin A1c (HbA1c) or serum insulin levels. The effect of cinnamon on fasting and postprandial blood glucose levels is inconclusive 70).
In conclusion, cinnamon should not be used in place of conventional medical care or to delay seeking care if you have health problems. This is particularly true if you have diabetes.
Cinnamon side effects
Side effects of cinnamon have been poorly documented in humans, because most research focusing on safety and efficacy has been conducted either in test tubes or in animals. Potential side effects found in animal studies include liver toxicity that results from coumarin isolates found in cinnamon cassia bark, decreased platelet counts, increased the risk of bleeding and allergy/hypersensitivity to cinnamon 71).
Cassia cinnamon contains varying amounts of a chemical called coumarin, which might cause or worsen liver disease. In 2008, The European Food Safety Authority considered toxicity of coumarin, a significant component of cinnamon, and confirmed a maximum recommended tolerable daily intake (TDI) of 0.1 mg of coumarin per kg of body weight. Coumarin is known to cause liver and kidney damage in high concentrations and metabolic effect in humans with CYP2A6 polymorphism 72). Based on this assessment, the European Union set a guideline for maximum coumarin content in foodstuffs of 50 mg per kg of dough in seasonal foods, and 15 mg per kg in everyday baked foods 73).
According to the maximum recommended tolerable daily intake (TDI) of 0.1 mg of coumarin per kg of body weight, which is 7 mg of coumarin for a body weight of 70 kg.
- Cinnamomum cassia (Chinese cinnamon) has 0.10 mg – 12.18 milligrams of coumarin per grams of cinnamon.
- Cinnamomum verum (Ceylon cinnamon) has less than 0.10 milligrams of coumarin per grams of cinnamon.
In most cases, cassia cinnamon doesn’t have enough coumarin to make you sick. However, for some people, such as those with liver disease, taking a large amount of cinnamon (coumarin) might worsen their condition 74). These possible effects may be a concern for patients with impaired liver function, concurrent anticoagulant or antiplatelet therapy, patients on antilipidemic agents, and those who are known to be hypersensitive to cinnamon or its components. There are reports of nonimmunologic contact urticaria occurring in people coming into contact with cinnamon products 75); however, because no human studies have been conducted to test this theory, these concerns remain hypothetical. Isolated case reports of cinnamon-induced stomatitis venenata (inflammation of the mucous lining of any of the structures in the mouth) secondary to contact allergy have been reported with consumption of the herb as a flavouring agent 76). However, there have been no documented adverse effects associated with the oral administration of cinnamon extract in clinical studies to date.
References [ + ]
|1, 44.||↵||Rao PV, Gan SH. Cinnamon: A Multifaceted Medicinal Plant. Evidence-based Complementary and Alternative Medicine : eCAM. 2014;2014:642942. doi:10.1155/2014/642942. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003790/|
|2, 39.||↵||Controversies surrounding the clinical potential of cinnamon for the management of diabetes. Rafehi H, Ververis K, Karagiannis TC. Diabetes Obes Metab. 2012 Jun; 14(6):493-9. https://www.ncbi.nlm.nih.gov/pubmed/22093965/|
|3.||↵||Battaglia S. The Complete Guide to Aromatherapy. Virginia, Queensland: The Perfect Potion, 1995.|
|4.||↵||Ody P. The Complete Medicinal Herbal. Ringwood: Viking Books, 1993.|
|5.||↵||Sangal A. Role of cinnamon as beneficial antidiabetic food adjunct: a review. Advances in Applied Science Research. 2011;2(4):440–450.|
|6.||↵||Vangalapati M, Sree Satya N, Surya Prakash D, Avanigadda S. A review on pharmacological activities and clinical effects of cinnamon species. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2012;3(1):653–663.|
|7.||↵||Cinnamon. National Center for Complementary and Integrative Health. https://nccih.nih.gov/health/cinnamon|
|8.||↵||Cinnamon. Wikipedia. https://en.wikipedia.org/wiki/Cinnamon|
|9.||↵||Huang T-C, Fu H-Y, Ho C-T, Tan D, Huang Y-T, Pan M-H. Induction of apoptosis by cinnamaldehyde from indigenous cinnamon Cinnamomum osmophloeum Kaneh through reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia K562 cells. Food Chemistry. 2007;103(2):434–443.|
|10.||↵||Methods for thermal stability enhancement of leaf essential oils and their main constituents from indigenous cinnamon (Cinnamomum osmophloeum). Yeh HF, Luo CY, Lin CY, Cheng SS, Hsu YR, Chang ST. J Agric Food Chem. 2013 Jul 3; 61(26):6293-8. https://www.ncbi.nlm.nih.gov/pubmed/23738884/|
|11.||↵||Antibacterial activities of plant essential oils against Legionella pneumophila. Chang CW, Chang WL, Chang ST, Cheng SS. Water Res. 2008 Jan; 42(1-2):278-86. https://www.ncbi.nlm.nih.gov/pubmed/17659763/|
|12.||↵||Supercritical CO2 extract of Cinnamomum zeylanicum: chemical characterization and antityrosinase activity. Marongiu B, Piras A, Porcedda S, Tuveri E, Sanjust E, Meli M, Sollai F, Zucca P, Rescigno A. J Agric Food Chem. 2007 Nov 28; 55(24):10022-7. https://www.ncbi.nlm.nih.gov/pubmed/17966976/|
|13.||↵||Cinnamomum cassia essential oil inhibits α-MSH-induced melanin production and oxidative stress in murine B16 melanoma cells. Chou ST, Chang WL, Chang CT, Hsu SL, Lin YC, Shih Y. Int J Mol Sci. 2013 Sep 18; 14(9):19186-201. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794828/|
|14.||↵||Nonaka G-I, Morimoto S, Nishioka I. Tannins and related compounds. Part 13. Isolation and structures of trimeric, tetrameric, and pentameric proanthicyanidins from cinnamon. Journal of the Chemical Society, Perkin Transactions 1. 1983:2139–2145.|
|15.||↵||Structure of polymeric polyphenols of cinnamon bark deduced from condensation products of cinnamaldehyde with catechin and procyanidins. Tanaka T, Matsuo Y, Yamada Y, Kouno I. J Agric Food Chem. 2008 Jul 23; 56(14):5864-70. https://www.ncbi.nlm.nih.gov/pubmed/18558701/|
|16.||↵||Catechins and procyanidins in berries of vaccinium species and their antioxidant activity. Määttä-Riihinen KR, Kähkönen MP, Törrönen AR, Heinonen IM. J Agric Food Chem. 2005 Nov 2; 53(22):8485-91. https://www.ncbi.nlm.nih.gov/pubmed/16248542/|
|17, 22.||↵||Wainstein J, Stern N, Heller S, et al. Dietary cinnamon supplementation and changes in systolic blood pressure in subjects with type 2 diabetes. Journal of Medicinal Food. 2011;14(12):1505-1510. https://www.ncbi.nlm.nih.gov/pubmed/21861719|
|18.||↵||Dugoua JJ, Seely D, Perri D, et al. From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark. Canadian Journal of Physiology and Pharmacology. 2007;85(9):837-847. https://www.ncbi.nlm.nih.gov/pubmed/18066129|
|19, 21, 69, 70.||↵||Leach MJ, Kumar S. Cinnamon for diabetes mellitus. Cochrane Database of Systematic Reviews 2012, Issue 9. Art. No.: CD007170. DOI: 10.1002/14651858.CD007170.pub2. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007170.pub2/full|
|20, 50, 68.||↵||Allen RW, Schwartzman E, Baker WL, Coleman CI, Phung OJ. Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis. Annals of Family Medicine. 2013;11(5):452-459. doi:10.1370/afm.1517. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767714/|
|23.||↵||Jakhetia V, Patel R, Khatri P, et al. Cinnamon: a pharmacological review. Journal of Advanced Scientific Research. 2010;1(2):19–12.|
|24.||↵||The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. Wondrak GT, Villeneuve NF, Lamore SD, Bause AS, Jiang T, Zhang DD. Molecules. 2010 May 7; 15(5):3338-55. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101712/|
|25.||↵||Hossein N, Zahra Z, Abolfazl M, Mahdi S, Ali K. Effect of Cinnamon zeylanicum essence and distillate on the clotting time. Journal of Medicinal Plants Research. 2013;7(19):1339–1343.|
|26.||↵||Minich St, Msom L. Chinese Herbal Medicine in Women’s Health. Women’s Health; 2008.|
|27.||↵||Gende LB, Floris I, Fritz R, Eguaras MJ. Antimicrobial activity of cinnamon (Cinnamomum zeylanicum) essential oil and its main components against paenibacillus larvae from argentine. Bulletin of Insectology. 2008;61(1):1–4.|
|28.||↵||Antifungal activities of essential oils and their constituents from indigenous cinnamon (Cinnamomum osmophloeum) leaves against wood decay fungi. Wang SY, Chen PF, Chang ST. Bioresour Technol. 2005 May; 96(7):813-8. https://www.ncbi.nlm.nih.gov/pubmed/15607195/|
|29.||↵||Kim N, Sung H, Kim W. Effect of solvents and some extraction conditions on antioxidant activity in cinnamon extracts. Korean Journal of Food Science and Technology. 1993;25(3):204–209.|
|30.||↵||The evaluation of long-term effects of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. Onderoglu S, Sozer S, Erbil KM, Ortac R, Lermioglu F. J Pharm Pharmacol. 1999 Nov; 51(11):1305-12. https://www.ncbi.nlm.nih.gov/pubmed/10632089/|
|31.||↵||Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum. Chao LK, Hua KF, Hsu HY, Cheng SS, Liu JY, Chang ST. J Agric Food Chem. 2005 Sep 7; 53(18):7274-8. https://www.ncbi.nlm.nih.gov/pubmed/16131142/|
|32.||↵||Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves. Tung YT, Yen PL, Lin CY, Chang ST. Pharm Biol. 2010 Oct; 48(10):1130-6. https://www.ncbi.nlm.nih.gov/pubmed/20815702/|
|33.||↵||Nematicidal Activity of Cassia and Cinnamon Oil Compounds and Related Compounds toward Bursaphelenchus xylophilus (Nematoda: Parasitaphelenchidae). Kong JO, Lee SM, Moon YS, Lee SG, Ahn YJ. J Nematol. 2007 Mar; 39(1):31-6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586484/|
|34.||↵||Chemical composition and mosquito larvicidal activity of essential oils from leaves of different Cinnamomum osmophloeum provenances. Cheng SS, Liu JY, Tsai KH, Chen WJ, Chang ST. J Agric Food Chem. 2004 Jul 14; 52(14):4395-400. https://www.ncbi.nlm.nih.gov/pubmed/15237942/|
|35.||↵||Insecticidal activities of leaf essential oils from Cinnamomum osmophloeum against three mosquito species. Cheng SS, Liu JY, Huang CG, Hsui YR, Chen WJ, Chang ST. Bioresour Technol. 2009 Jan; 100(1):457-64. https://www.ncbi.nlm.nih.gov/pubmed/18396039/|
|36.||↵||Bioactivity of cinnamon with special emphasis on diabetes mellitus: a review. Bandara T, Uluwaduge I, Jansz ER. Int J Food Sci Nutr. 2012 May; 63(3):380-6. https://www.ncbi.nlm.nih.gov/pubmed/22007625/|
|37.||↵||Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. Koppikar SJ, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R. BMC Cancer. 2010 May 18; 10():210. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893107/|
|38.||↵||Comparative study of cinnamon oil and clove oil on some oral microbiota. Gupta C, Kumari A, Garg AP, Catanzaro R, Marotta F. Acta Biomed. 2011 Dec; 82(3):197-9. https://www.ncbi.nlm.nih.gov/pubmed/22783715/|
|40.||↵||[Comparison studies on chemical constituents of essential oil from Ramulus Cinnamomi and Cortex Cinnamomi by GC-MS]. Shen Q, Chen F, Luo J. Zhong Yao Cai. 2002 Apr; 25(4):257-8. https://www.ncbi.nlm.nih.gov/pubmed/12583177/|
|41.||↵||Cinnamon and health. Gruenwald J, Freder J, Armbruester N. Crit Rev Food Sci Nutr. 2010 Oct; 50(9):822-34. https://www.ncbi.nlm.nih.gov/pubmed/20924865/|
|42.||↵||Paranagama PA, Wimalasena S, Jayatilake GS, Jayawardena AL, Senanayake UM, Mubarak AM. A comparison of essential oil constituents of bark, leaf root and fruit of cinnamon (cinnamomum zeylanicum Blum), grown in Sri Lanka. J Natl Sci Found Sri. 2010;29:147–153.|
|43.||↵||United States Department of Agriculture Agricultural Research Service. National Nutrient Database for Standard Reference Release 28. https://ndb.nal.usda.gov/ndb/search/list|
|45.||↵||Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care. 2004;27(5):1218–24. doi: 10.2337/diacare.27.5.1218. https://www.ncbi.nlm.nih.gov/pubmed/15111553|
|46.||↵||Garrow D, Egede LE. Association between complementary and alternative medicine use, preventive care practices, and use of conventional medical services among adults with diabetes. Diabetes care. 2006;29(1):15–19. doi: 10.2337/diacare.29.01.06.dc05-1448. https://www.ncbi.nlm.nih.gov/pubmed/16373889|
|47.||↵||Bell RA, Suerken CK, Grzywacz JG, Lang W, Quandt SA, Arcury TA. Complimentary and alternative medicine use among adults with diabetes in the United Sates. Altern Ther Health Med. 2006;12(5):16–22. https://www.ncbi.nlm.nih.gov/pubmed/17017751|
|48.||↵||Ranasinghe P, Jayawardena R, Galappathy P, Constantine GR, de Vas gunawardena N, Katulanda P. Efficacy and safety of ‘true’ cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med. 2012;29(12):1480–92. doi: 10.1111/j.1464-5491.2012.03718.x. https://www.ncbi.nlm.nih.gov/pubmed/22671971|
|49.||↵||Herman PM. Evaluating the Economics of Complementary and Integrative Medicine. Global Advances in Health and Medicine. 2013;2(2):56-63. doi:10.7453/gahmj.2013.002. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833528/|
|51, 54, 61, 64, 67.||↵||Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. Blevins SM, Leyva MJ, Brown J, Wright J, Scofield RH, Aston CE. Diabetes Care. 2007 Sep; 30(9):2236-7. https://www.ncbi.nlm.nih.gov/pubmed/17563345/|
|52.||↵||Dietary cinnamon supplementation and changes in systolic blood pressure in subjects with type 2 diabetes. Wainstein J, Stern N, Heller S, Boaz M. J Med Food. 2011 Dec; 14(12):1505-10. https://www.ncbi.nlm.nih.gov/pubmed/21861719/|
|53, 66.||↵||Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. Vanschoonbeek K, Thomassen BJ, Senden JM, Wodzig WK, van Loon LJ. J Nutr. 2006 Apr; 136(4):977-80. http://jn.nutrition.org/content/136/4/977.long|
|55, 58.||↵||Cinnamon improves glucose and lipids of people with type 2 diabetes. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Diabetes Care. 2003 Dec; 26(12):3215-8. https://www.ncbi.nlm.nih.gov/pubmed/14633804/|
|56, 59, 63.||↵||Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Akilen R, Tsiami A, Devendra D, Robinson N. Diabet Med. 2010 Oct; 27(10):1159-67. https://www.ncbi.nlm.nih.gov/pubmed/20854384/|
|57, 60.||↵||Khan R, Khan Z, Shah S. Cinnamon may reduce glucose, lipid and cholesterol level in type 2 diabetic individuals. Pakistan J Nutr. 2010; 9(5):430–433.|
|62, 65.||↵||Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A. Eur J Clin Invest. 2006 May; 36(5):340-4. https://www.ncbi.nlm.nih.gov/pubmed/16634838/|
|71.||↵||Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. American Diabetes Association., Bantle JP, Wylie-Rosett J, Albright AL, Apovian CM, Clark NG, Franz MJ, Hoogwerf BJ, Lichtenstein AH, Mayer-Davis E, Mooradian AD, Wheeler ML. Diabetes Care. 2008 Jan; 31 Suppl 1():S61-78. https://www.ncbi.nlm.nih.gov/pubmed/18165339/|
|72, 73.||↵||Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the European Commission on Coumarin in flavourings and other food ingredients with flavouring properties. The EFSA Journal (2008) 793, 1–15. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2008.793/pdf|
|74.||↵||Lungarini S, Aureli F, Coni E. Coumarin and cinnamaldehyde in cinnamon marketed in Italy: a natural chemical hazard? Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment. 2008;25(11):1297-1305. https://www.ncbi.nlm.nih.gov/pubmed/19680836|
|75.||↵||An evidence-based systematic review of cinnamon (Cinnamomum spp.) by the Natural Standard Research Collaboration. Ulbricht C, Seamon E, Windsor RC, Armbruester N, Bryan JK, Costa D, Giese N, Gruenwald J, Iovin R, Isaac R, Serrano JM, Tanguay-Colucci S, Weissner W, Yoon H, Zhang J. J Diet Suppl. 2011 Dec; 8(4):378-454. https://www.ncbi.nlm.nih.gov/pubmed/22432776/|
|76.||↵||De Rossi SS, Greenberg MS. Intraoral contact allergy: a literature review and case reports. Journal of the American Dental Association 1998;129:1435-41. https://www.ncbi.nlm.nih.gov/pubmed/9787540|